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spacer Department of Inorganic and Physical Chemistry spacer
Mugesh's Group spacer spacer
Department of
Inorganic and Physical Chemistry

Lactoperoxidase Active site of Fe-containing Lactoperoxidase

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Bioinorganic and Biomimetic Chemistry

The main focus of our research is to understand the chemistry and biology of naturally occuring and chemically modified metalloproteins (including selenoproteins) and to develop new approaches for modeling/mimicking the enzymatic properties with purposefully-designed small molecules. Our group is also interested in the design and synthesis of novel sulfur and selenium-containing compounds as inhibitors of thyroid peroxidase and lactoperoxidase. We employ spectroscopic, crystallographic and biophysical methods in combination with chemical synthesis to accomplish these objectives.

Representative Publications

Manna, D.; Mugesh, G. "Regioselective Deiodination of Thyroxine by Iodothyronine Deiodinase Mimics: An Unusual Mechanistic Pathway Involving Cooperative Chalcogen and Halogen Bonding",
J. Am. Chem. Soc. 134, 4269 - 4279 (2012).

Manna, D.; Mugesh, G. "Deiodination of Thyroid Hormones by Iodothyronine Deiodinase Mimics: Does an Increase in the Reactivity Alter the Regioselectivity?",
J. Am. Chem. Soc. 133, 9980 - 9983 (2011).

Manna, D.; Mugesh, G. "A Chemical Model for the Inner-Ring Deiodination of Thyroxine by Iodothyronine Deiodinase",
Angew. Chem. Int. Ed., 49, 9246 - 9249 (2010).

Sarma, B. K.; Manna, D.; Minoura, M.; Mugesh, G. "Synthesis, Structure, Spirocyclization Mechanism and Glutathione Peroxidase-like Antioxidant Activity of Stable Spirodiazaselenurane and Spirodiazatellurane",
J. Am. Chem. Soc., 132, 5364 - 5374 (2010).

Sarma, B. K.; Mugesh, G. "Redox Regulation of Protein Tyrosine Phosphatase 1B (PTP1B): A Biomimetic Study on the Unexpected Formation of a Sulfenyl Amide Intermediate",
J. Am. Chem. Soc. 129, 8872 - 8881 (2007).

Roy, G.; Mugesh, G. "Anti-Thyroid Drugs and Thyroid Hormone Synthesis: Effect of Methimazole Derivatives on Peroxidase-Catalyzed Reactions",
J. Am. Chem. Soc. 127, 15207 - 15217 (2005).

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G. Mugesh

IPC Department
Indian Institute of Science
Bangalore 560 012, INDIA
email :

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MSeI The selenium analogue of methimazole, an anti-thyroid drug

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